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January 31, 2017Echocardiography

Assessment of left ventricular functions and myocardial iron load with tissue Doppler and speckle tracking echocardiography and T2* MRI in patients with β‐thalassemia major

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Key result

β-thalassemia major patients exhibited significantly lower global circumferential strain and longer isovolumic contraction times compared to controls, correlating with myocardial iron load.

Why the study?

Can tissue Doppler imaging and speckle tracking echocardiography detect early myocardial dysfunction and correlate with myocardial iron load in patients with β-thalassemia major?

Population

60 individuals, comprising 30 patients with β-thalassemia major (BTM) and 30 individuals in the control group

Comparison

Tissue Doppler imaging and speckle tracking… vs Control group and T2* magnetic resonance imaging

Design

Case-control

Authors

MAMehmet Emre ArıFEFiliz EkiciİÇİbrahim İlker Çetin

Discussion

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Member takes

Overview

May aid early myocardial dysfunction detection in BTM; leaves open whether screening improves outcomes.

Study Design

Type

Case-Control (n=60)

Structured PICO

Can tissue Doppler imaging and speckle tracking echocardiography detect early myocardial dysfunction and correlate with myocardial iron load in patients with β-thalassemia major?

P
Population
60 individuals, comprising 30 β-thalassemia major patients and 30 healthy controls, evaluated for early myocardial dysfunction.
E
Exposure
Tissue Doppler imaging (TDI) and speckle tracking echocardiography (STE)
C
Comparator
Control group (healthy individuals) and T2* magnetic resonance imaging (as reference for cardiac iron deposition)
O
Outcome
Early myocardial dysfunction parameters, including isovolumic contraction time, global circumferential strain, and longitudinal strainsurrogate

Tissue Doppler imaging and speckle tracking echocardiography, particularly circumferential strain, can serve as early screening tools for myocardial dysfunction related to iron overload in β-thalassemia major.

Cite This Study

Arı et al. (2017) conducted a case-control in β-thalassemia major (n=60). β-thalassemia major vs. Healthy controls was evaluated on Myocardial dysfunction assessed by tissue Doppler imaging, speckle tracking echocardiography, and T2* MRI. β-thalassemia major patients exhibited significantly lower global circumferential strain and longer isovolumic contraction times compared to controls, correlating with myocardial iron load.

synapsesocial.com/papers/6a97f5bfb588d5324d36788ehttps://doi.org/10.1111/echo.13463
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