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February 4, 2018Echocardiography

The correlation between cardiac magnetic resonance T2* and left ventricular global longitudinal strain in people with β‐thalassemia

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Key result

Abnormal cardiac iron load in β-thalassemia was associated with significantly lower global longitudinal strain (P<.0001), with a GLS cutoff of -18.5% predicting T2* <20 ms (AUC 0.742).

Why the study?

Does left ventricular global longitudinal strain correlate with cardiac magnetic resonance T2* to predict myocardial iron overload in individuals with β-thalassemia?

Population

130 individuals with β-thalassemia

Comparison

Left ventricular global longitudinal strain… vs Cardiac magnetic resonance T2* imaging

Design

Cross-sectional

Authors

MPMozhgan ParsaeeNANehzat AkiashAAAzita Azarkeivan

Discussion

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Overview

GLS may aid noninvasive detection of iron overload in β-thalassemia; hypothesis-generating and requires prospective validation.

Study Design

Type

Cross-Sectional (n=130)

Structured PICO

Does left ventricular global longitudinal strain correlate with cardiac magnetic resonance T2* to predict myocardial iron overload in individuals with β-thalassemia?

P
Population
130 individuals with β-thalassemia evaluated for the correlation between cardiac T2* MRI and left ventricular global longitudinal strain.
E
Exposure
Left ventricular global longitudinal strain (GLS) measurement via two- and three-dimensional echocardiography (speckle tracking method)
C
Comparator
Cardiac magnetic resonance T2* imaging (reference standard for cardiac iron load)
O
Outcome
Correlation between cardiac T2* MRI and left ventricular global longitudinal strain, and diagnostic accuracy of GLS to predict T2* <20 mssurrogate

Main Result

Effect estimate: AUC 0.742

p-value: p=<.0001

Global longitudinal strain via echocardiography is a useful and accessible tool to predict myocardial iron overload in patients with β-thalassemia, correlating significantly with the gold-standard cardiac MRI T2*.

Cite This Study

Parsaee et al. (2018) conducted a cross-sectional in β-thalassemia (n=130). Abnormal cardiac iron load vs. Normal cardiac iron load was evaluated on Left ventricular global longitudinal strain (GLS) (AUC 0.742, p=<.0001). Abnormal cardiac iron load in β-thalassemia was associated with significantly lower global longitudinal strain (P<.0001), with a GLS cutoff of -18.5% predicting T2* <20 ms (AUC 0.742).

synapsesocial.com/papers/6a848d90c7e37ebe3168e67ehttps://doi.org/10.1111/echo.13801
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Assessment of left ventricular functions and myocardial iron load with tissue Doppler and speckle tracking echocardiography and T2* MRI in patients with β‐thalassemia major2017 · 28 citations
  2. 2A two-dimensional speckle-tracking echocardiography for the diagnosis of early myocardial disease in beta-thalassemia major patients2022 · 5 citations
  3. 3Value of speckle tracking echocardiography for detection of clinically silent left ventricular dysfunction in patients with β-thalassemia2017 · 21 citations
  4. 4Quantification of myocardial iron deposition by two-dimensional speckle tracking in patients with β-thalassaemia major and Blackfan–Diamond anaemia2011 · 38 citations
  5. 5Strain Imaging by Speckle Tracking for the Assessment of Diastolic Dysfunction in Beta-Thalassemia Major Patients2021 · 3 citations