Key result
Asymptomatic children with beta-thalassemia major show decreased LV global strains versus healthy controls.
Why the study?
The role of real-time three-dimensional and speckle tracking echocardiography for early detection of left ventricular systolic dysfunction in asymptomatic children with beta-thalassemia major was evaluated.
Does real-time three-dimensional and speckle tracking echocardiography detect early left ventricular systolic dysfunction in asymptomatic children with beta-thalassemia major?
Population
40 asymptomatic children with beta-thalassemia major and 40 healthy matched children
Comparison
Beta-thalassemia major patients vs healthy matched children
Design
Multicenter cross-sectional study
Authors
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Speckle tracking may identify subclinical LV dysfunction in asymptomatic beta-thalassemia children; leaves open prognostic value and management implications.
Cross-Sectional (n=80)
Yes
Does real-time three-dimensional and speckle tracking echocardiography detect early left ventricular systolic dysfunction in asymptomatic children with beta-thalassemia major?
p-value: p=0.029, p<0.001, p=0.003
Real-time 3D and speckle tracking echocardiography can detect subclinical left ventricular systolic dysfunction in asymptomatic children with beta-thalassemia major, irrespective of myocardial iron load.
Eroğlu et al. (2022) conducted a cross-sectional in Beta-thalassemia major (n=80). Beta-thalassemia major vs. Healthy children was evaluated on Left ventricular global longitudinal, circumferential, and radial strains (p=p=0.029, p<0.001, p=0.003). Asymptomatic children with beta-thalassemia major had decreased left ventricular global longitudinal, circumferential, and radial strains compared to healthy controls (p=0.029, p<0.001, p=0.003).
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