Why the study?
Does intravenous atropine improve peak expiratory flow rate in patients with nocturnal asthma?
Population
10 patients with asthma who had a diurnal variation in peak expiratory flow rate of greater than 20%
Comparison
30 micrograms/kg of intravenous atropine at 4 am… vs Placebo at 4 am and 4 pm
Authors
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May improve nocturnal asthma; hypothesis-generating for vagal mechanisms pending randomized confirmation.
Does intravenous atropine improve peak expiratory flow rate in patients with nocturnal asthma?
Intravenous atropine significantly reverses nocturnal asthma, suggesting vagal mechanisms play a fundamental role in its pathophysiology.
Morrison et al. (1988) studied this question.
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