March 5, 2007European Journal of Heart Failure

Plasma B-Type Natriuretic Peptide Concentration in β-Thalassaemia Patients

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Why the study?

Does plasma BNP concentration have diagnostic and prognostic value in the evaluation of thalassaemia heart disease?

Population

83 thalassaemia major patients and 50 healthy controls.

Comparison

Plasma B-type natriuretic peptide determination vs Healthy controls and comparison across different…

Design

Cross-sectional

Authors

AAAthanasios AessoposLaiko General Hospital of Athens DFDimitrios FarmakisHeart Failure / Cardiomyopathy APAikaterini PolonifiNational and Kapodistrian University of Athens

Discussion

Member takes

Implication

BNP elevation flags acute decompensation in thalassaemia but not milder impairment; leaves open its diagnostic value pending longitudinal data.

Structured PICO

Does plasma BNP concentration have diagnostic and prognostic value in the evaluation of thalassaemia heart disease?

Population

83 thalassaemia major patients (8 with acutely decompensated heart failure NYHA class III or IV [group A], 25 with NYHA class II symptoms and impaired systolic left ventricular function [ejection fraction<55% or fractional shortening<30%, group B], and 50 with normal systolic function [group C]) and 50 healthy controls.

Intervention

Plasma B-type natriuretic peptide (BNP) determination

Comparator

Healthy controls and comparison across different thalassaemia patient groups

Outcome

Plasma BNP concentration and its correlation with echocardiographic parameters and serum ferritinsurrogate

Plasma BNP is elevated in acutely decompensated heart failure in thalassaemia major but fails to differentiate between mild systolic impairment and normal systolic function, limiting its clinical utility in this population.

Cite This Study

Aessopos et al. (2007) studied this question.

synapsesocial.com/papers/6a7eb803b2811efa75cda542 https://doi.org/10.1016/j.ejheart.2006.12.004

Topics

HFrEF treatment Heart failure

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Implication

BNP elevation flags acute decompensation in thalassaemia but not milder impairment; leaves open its diagnostic value pending longitudinal data.

Plasma B-Type Natriuretic Peptide Concentration in β-Thalassaemia Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Plasma B-Type Natriuretic Peptide Concentration in β-Thalassaemia Patients

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider