Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
June 1, 2001BloodOpen Access

Cardiac involvement in thalassemia intermedia: a multicenter study

View Full Paper
Ask AI
Bookmark
Share

Population

110 patients with thalassemia intermedia and 76 healthy controls.

Design

Cross-sectional

Authors

AAAthanasios AessoposDFDimitrios FarmakisMKMarkisia Karagiorga

Discussion

Loading...

Member takes

Overview

PH warrants monitoring in thalassemia intermedia; hypothesis-generating and requires prospective validation before guiding practice.

Structured PICO

P
Population
110 patients with thalassemia intermedia (mean age 32.5 +/- 11.4 years; 67 not/minimally transfused, 43 started transfusions after age 5) and 76 healthy controls.
C
Comparator
Healthy controls
O
Outcome
Prevalence of cardiac complications including congestive heart failure, pericarditis, and echocardiographic abnormalities (pulmonary hypertension, valvular involvement, left ventricular contractility).

In patients with thalassemia intermedia, pulmonary hypertension driven by high cardiac output and increased pulmonary vascular resistance is highly prevalent and is the primary cause of congestive heart failure.

Cite This Study

Aessopos et al. (2001) studied this question.

synapsesocial.com/papers/6a7eb803b2811efa75cda545https://doi.org/10.1182/blood.v97.11.3411
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1M-Mode and Two-dimensional Echocardiographic Abnormalities in Systemic Lupus Erythematosus1985 · 69 citations
  2. 2Reconsideration of echocardiographic standards for mitral valve prolapse: Lack of association between leaflet displacement isolated to the apical four chamber view and independent echocardiographic evidence of abnormality1988 · 315 citations
  3. 3Pseudoxanthoma Elasticum and Mitral-Valve Prolapse1982 · 126 citations