February 1, 1986Journal of Clinical InvestigationOpen Access

The mean rate of entry of endogenous TxB2 into the circulation was calculated as 0.11 ng/kg x min, corresponding to a maximal estimate of the plasma concentration of endogenous TxB2 of 2.0 pg/ml.

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Population

4 healthy male volunteers

Comparison

6-h i.v. infusions of TxB2 at 0.1, 1.0, and 5.0… vs 6-h i.v. infusion of vehicle alone

Design

Other, random order

Follow-up

up to 24 hours after infusions

Authors

GCGiovanni Ciabattoni FPFrancesco Pugliese APAlessandro Pierucci

Discussion

Member takes

Overview

Plasma TxB2 assays likely overestimate endogenous levels via ex vivo activation; leaves open validity of prior thromboxane measurements in cardiovascular research.

Structured PICO

Population

4 healthy male volunteers

Intervention

6-h i.v. infusions of TxB2 at 0.1, 1.0, and 5.0 ng/kg x min, pretreated with aspirin 325 mg/d

Comparator

6-h i.v. infusion of vehicle alone

Outcome

Urinary excretion of 2,3-dinor-TxB2 and estimated rate of entry of endogenous TxB2 into the circulationsurrogate

This physiological study provides an estimate of endogenous thromboxane release and suggests that ex vivo platelet activation confounds estimates based on plasma TxB2.

Cite This Study

Ciabattoni et al. (1986) studied this question.

synapsesocial.com/papers/6a7ec692cb17bc2d1d0d2986 https://doi.org/10.1172/jci112341

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February 1, 1986Journal of Clinical InvestigationOpen Access

The mean rate of entry of endogenous TxB2 into the circulation was calculated as 0.11 ng/kg x min, corresponding to a maximal estimate of the plasma concentration of endogenous TxB2 of 2.0 pg/ml.

View Full Paper

Ask AI

Bookmark

Population

4 healthy male volunteers

Comparison

6-h i.v. infusions of TxB2 at 0.1, 1.0, and 5.0… vs 6-h i.v. infusion of vehicle alone

Design

Other, random order

Follow-up

up to 24 hours after infusions

Authors

GCGiovanni Ciabattoni FPFrancesco Pugliese APAlessandro Pierucci

Discussion

Member takes

Overview

Plasma TxB2 assays likely overestimate endogenous levels via ex vivo activation; leaves open validity of prior thromboxane measurements in cardiovascular research.

Structured PICO

Population

4 healthy male volunteers

Intervention

6-h i.v. infusions of TxB2 at 0.1, 1.0, and 5.0 ng/kg x min, pretreated with aspirin 325 mg/d

Comparator

6-h i.v. infusion of vehicle alone

Outcome

Urinary excretion of 2,3-dinor-TxB2 and estimated rate of entry of endogenous TxB2 into the circulationsurrogate

This physiological study provides an estimate of endogenous thromboxane release and suggests that ex vivo platelet activation confounds estimates based on plasma TxB2.

Cite This Study

Ciabattoni et al. (1986) studied this question.

synapsesocial.com/papers/6a7ec692cb17bc2d1d0d2986 https://doi.org/10.1172/jci112341

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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