What question did this study set out to answer?

To evaluate longitudinal changes in cutaneous phosphorylated alpha-synuclein deposition, its relationship to clinical progression, and its concordance with cerebrospinal fluid seed amplification assays in early multiple system atrophy.

August 14, 2026Clinical Autonomic ResearchOpen Access

Cutaneous alpha-synuclein deposition informs autonomic function in individuals with early-stage multiple system atrophy

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Authors

PTPaula TrujilloVanderbilt University LMLeah MannVanderbilt University Medical Center BBBailey BellaireScottsdale Research Institute (United States)

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Implication

Cohort study reveals increasing skin alpha-synuclein deposition tracks worsening autonomic dysfunction in early multiple system atrophy, indicating utility as a disease progression biomarker.

Key Points

To evaluate longitudinal changes in cutaneous phosphorylated alpha-synuclein deposition, its relationship to clinical progression, and its concordance with cerebrospinal fluid seed amplification assays in early multiple system atrophy.
Enrolled 17 participants with probable multiple system atrophy in a 12-month longitudinal cohort study.
Performed repeated clinical evaluations, brain imaging, fluid biomarker testing, and skin biopsies from posterior cervical and distal thigh sites.
Quantified phosphorylated alpha-synuclein with immunofluorescence microscopy and compared detection rates to cerebrospinal fluid seed amplification assays.
Cutaneous alpha-synuclein deposition increased significantly over the 12-month follow-up period.
Greater alpha-synuclein accumulation correlated with worsening autonomic symptom severity scores, but did not correlate with global disease severity or neurofilament light chain levels.
Skin biopsies successfully detected phosphorylated alpha-synuclein in two participants who tested negative on cerebrospinal fluid seed amplification assays.

Cite This Study

Trujillo et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec69fb70b84ec8b912c36 https://doi.org/10.1007/s10286-026-01235-y

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Implication

Cohort study reveals increasing skin alpha-synuclein deposition tracks worsening autonomic dysfunction in early multiple system atrophy, indicating utility as a disease progression biomarker.

Cutaneous alpha-synuclein deposition informs autonomic function in individuals with early-stage multiple system atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

Cutaneous alpha-synuclein deposition informs autonomic function in individuals with early-stage multiple system atrophy

Discussion

Member takes

Implication

Key Points

Cite This Study

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