Gut microbiota–derived ergothioneine: a promising neuroprotective metabolite against antipsychotic‑induced cognitive decline

Jun-Wei Cao; Zebin Fan; Xiaoping Wang

doi:10.1093/pcmedi/pbag022

August 12, 2026Precision Clinical MedicineOpen Access

Gut microbiota–derived ergothioneine: a promising neuroprotective metabolite against antipsychotic‑induced cognitive decline

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Key Points

To evaluate the neuroprotective role of gut microbiota-derived ergothioneine in counteracting cognitive decline associated with antipsychotic medication use.
Analysis of microbial metabolic pathways producing ergothioneine and their interactions with the gut-brain axis during antipsychotic therapy.
Ergothioneine synthesized by gut bacteria functions as a potent neuroprotective metabolite that mitigates antipsychotic-induced cognitive side effects.

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Implication

Review highlights gut microbiota–derived ergothioneine as a neuroprotective metabolite against drug-related cognitive impairment, suggesting novel therapeutic avenues.

Abstract

Jun-Wei Cao, Zebin Fan, Xiaoping Wang; Gut microbiota–derived ergothioneine: a promising neuroprotective metabolite against antipsychotic‑induced cognitive

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Cite This Study

Cao et al. (2026) studied this question.

synapsesocial.com/papers/6a7ec7bab70b84ec8b914633 https://doi.org/10.1093/pcmedi/pbag022

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Gut microbiota–derived ergothioneine: a promising neuroprotective metabolite against antipsychotic‑induced cognitive decline

Key Points

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Implication

Abstract

Discussion

Cite This Study

Gut microbiota–derived ergothioneine: a promising neuroprotective metabolite against antipsychotic‑induced cognitive decline

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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