Non-linear association between body weight and functional outcome after acute ischemic stroke

Figures

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  Figure 1. Relationship between body mass index and unfavorable clinical outcomes at 3 months. The associations between body mass index and the risk of a poor functional outcome (a), functional disability (b), or death (c) at 3 months after onset are shown. ORs (solid lines) and 95% CIs (dotted lines) were estimated in reference to a body mass index of 18.5 kg/m2 using a logistic regression model and are shown by restricted cubic spline curves. The multivariable model included age, sex, hypertension, diabetes mellitus, dyslipidemia, atrial fibrillation, waist circumference, prior stroke, pre-stroke functional status, stroke subtype, the National Institutes of Health Stroke Scale score on admission, and reperfusion therapy. OR odds ratio, CI confidence interval.

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  Figure 2. SHAP values of body mass index for unfavorable clinical outcomes at 3 months. SHAP values of the body mass index in predicting a poor functional outcome (a), functional disability (b), or death (c) at 3 months after onset in 11 body mass index categories are shown. SHAP values for post-stroke clinical outcomes were calculated in a decision tree ensemble model. Boxes, horizontal lines, and vertical lines indicate the interquartile range, median, and 5–95 percentiles, respectively, of SHAP values for each clinical outcome in 11 groups according to body mass index in increments of 2 (body mass index groups: < 16 kg/m2, increment of 2 from 16 to 33.9 kg/m2, and ≥ 34 kg/m2). SHAP SHapley Additive exPlanation.