Why the study?
Does lisinopril or bisoprolol influence insulin sensitivity in healthy volunteers when body weight and potassium homeostasis are controlled?
Population
22 healthy volunteers, mean age 27 ± 3 years, BMI 22.0 ± 1.5 kg/m²
Comparison
Lisinopril 5 mg or Bisoprolol 5 mg administered… vs Cross-over design
Design
RCT, randomized, double-blind
Follow-up
4 weeks per drug phase
Authors
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Neither lisinopril nor bisoprolol alters insulin sensitivity; confirms neutral metabolic effects in healthy volunteers when weight and potassium are controlled.
Does lisinopril or bisoprolol influence insulin sensitivity in healthy volunteers when body weight and potassium homeostasis are controlled?
In healthy normotensive subjects, 4-week administration of lisinopril or bisoprolol does not significantly influence insulin sensitivity when body weight and potassium levels are strictly controlled.
Heinemann et al. (1995) studied this question.
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