Why the study?
Does enalapril improve insulin sensitivity and serum lipoprotein concentration compared to atenolol in obese hypertensive dyslipidemic patients?
Population
28 obese, hypertensive, dyslipidemic outpatients
Comparison
Enalapril for 12 weeks vs Atenolol for 12 weeks
Design
RCT, randomized in two groups, investigator-blinded
Follow-up
12 weeks
Authors
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Supports enalapril over atenolol for metabolic effects in obese dyslipidemic hypertensives; confirms ACEI advantage independent of BP reduction.
Does enalapril improve insulin sensitivity and serum lipoprotein concentration compared to atenolol in obese hypertensive dyslipidemic patients?
Enalapril improves insulin sensitivity compared to atenolol in obese hypertensive dyslipidemic patients, despite similar blood pressure lowering efficacy.
Morel et al. (1995) studied this question.
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