Why the study?
Does intrathecal administration of tempol improve arterial baroreflex control of renal sympathetic nerve activity in male Wistar rats?
Does intrathecal administration of tempol improve arterial baroreflex control of renal sympathetic nerve activity in male Wistar rats?
Intrathecal administration of the antioxidant tempol increases renal reflex sympathoinhibitory responses, suggesting that spinal reactive oxygen species exert a tonic inhibitory influence on barosensitive neurons.
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No immediate clinical implications; leaves open whether spinal ROS inhibition enhances baroreflex control in humans.
Clinical and experimental studies have shown that sustained increase in renal sympathetic nerve activity (rSNA) contributes to hypertension. Previous studies by our group showed that antioxidant treatments improve arterial baroreceptor reflex, which is a powerful beat-to-beat negative feedback control of arterial blood pressure (BP).
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Nishi et al. (2017) studied this question.
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