Population
Mammalian cell lines including HeLa, Rat-1 fibroblasts, NIH 3T3 fibroblasts (3T3 and 3T3), and mouse…
Comparison
Treatment with synthetic double-stranded RNA via… vs Untreated cells, cells treated with Lipofectin…
Design
Preclinical
Authors
Loading...
Alternative dsRNA-MAPK pathways bypass RNase L/PKR; leaves open their therapeutic targeting in viral inflammation pending human studies.
Demonstrates the existence of alternative RNase L- and PKR-independent dsRNA-triggered signaling pathways that stimulate stress-activated MAPKs, with p38 MAPK mediating inflammatory responses to viral infections.
Iordanov et al. (2000) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: