Why the study?
Do cardiac glycosides have a direct negative chronotropic effect on the mammalian sinoatrial node independent of autonomic neural control?
Population
Anesthetized cats and dogs, and isolated rabbit right atrium perfused with Tyrode's solution
Design
Preclinical
Authors
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Challenges direct SA node effects of cardiac glycosides in mammals; leaves open translation to human physiology and practice.
Do cardiac glycosides have a direct negative chronotropic effect on the mammalian sinoatrial node independent of autonomic neural control?
Cardiac glycosides do not have a direct negative chronotropic action on the mammalian sinoatrial node; their sinus slowing effect is mediated entirely by alteration of neural control.
Eick et al. (1969) studied this question.
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