Key result
Resectable non-small cell lung cancer was associated with a significantly higher prevalence of abdominal aortic aneurysm compared to cancer-free controls (3.8% vs 0.2%; OR 19.19).
Why the study?
Abdominal aortic aneurysm is more common in non-small cell lung cancer patients, and timely management could confer survival benefits, prompting assessment of its prevalence and characteristics in resectable cases.
Does the presence of resectable non-small cell lung cancer increase the prevalence of abdominal aortic aneurysm compared to cancer-free controls?
Population
1,019 resectable NSCLC patients and 2,899 cancer-free controls
Comparison
Resectable NSCLC patients vs cancer-free controls
Design
Cross-sectional study
Authors
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May warrant reviewing the aorta on existing staging CT; leaves open whether dedicated AAA surveillance improves outcomes.
Cross-Sectional (n=3,918)
Yes
Does the presence of resectable non-small cell lung cancer increase the prevalence of abdominal aortic aneurysm compared to cancer-free controls?
Odds Ratio: 19.19 (95% CI 8.1–46.46)
Absolute Event Rate: 3.8% vs 0.2%
p-value: p=<0.001
Patients with resectable early-stage non-small cell lung cancer have a significantly higher prevalence of abdominal aortic aneurysm, suggesting a potential benefit for routine AAA surveillance in this population, particularly among older male smokers.
Gwon et al. (2025) conducted a cross-sectional in Non-small cell lung cancer (NSCLC) (n=3,918). Resectable non-small cell lung cancer vs. Cancer-free individuals was evaluated on Prevalence of abdominal aortic aneurysm (AAA) (OR 19.19, 95% CI 8.10-46.46, p=<0.001). Resectable non-small cell lung cancer was associated with a significantly higher prevalence of abdominal aortic aneurysm compared to cancer-free controls (3.8% vs 0.2%; OR 19.19).
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