Key result
The presence of an abdominal aortic aneurysm in lung cancer patients was associated with a higher risk of all-cause mortality compared to matched controls without AAA.
Why the study?
Major causes of death in abdominal aortic aneurysm patients are cardiovascular disease and cancer, but the effect of abdominal aortic aneurysm on long-term survival in lung cancer patients was unknown.
Does the presence of an abdominal aortic aneurysm increase all-cause mortality in lung cancer patients?
Cohort (n=4,780)
Does the presence of an abdominal aortic aneurysm increase all-cause mortality in lung cancer patients?
The presence of an abdominal aortic aneurysm, particularly when untreated, significantly increases the long-term mortality risk in patients with lung cancer, highlighting the need for continuous cardiovascular risk management.
Answers are grounded in this paper and cite their sources.
AAA may raise mortality risk in lung cancer, especially if unrepaired; leaves open whether repair improves outcomes in prospective studies.
The major causes of death in patients with abdominal aortic aneurysm (AAA) are cardiovascular disease and cancer. The purpose of this study was to evaluate the effect of AAA on long-term survival in lung cancer patients. All patient data with degenerative type AAA and lung cancer over 50 years of age during the period 2009 to 2018 was collected retrospectively from a National Health Insurance Service (NHIS) administrative database and matched to lung cancer patients without AAA by age, sex, metastasis, and other comorbidities. Mortality rate was compared between the groups. A total of 956 AAA patients who could be matched with patients without AAA were included, and 3824 patients in the matched group were used for comparison. Patients with AAA showed higher risk of death compared with the matched cohort (adjusted hazard ratio (HR) 1.14, 95% confidence interval (CI) 1.06-1.23, p < 0.001). When compared to a matched group of untreated AAA patients, patients with of history of AAA exhibited a significantly increased risk of overall mortality [HR (95%CI) 1.219 (1.113-1.335), p < .001, adjusted HR (95% CI) 1.177 (1.073-1.291), p = .001]. By contrast, mortality risk of AAA patients treated either by endovascular abdominal aortic repair or open surgical repair was not significantly different from that of the matched group (p = 0.079 and p = 0.625, respectively). The mortality risk was significantly higher when AAA was present in lung cancer patients, especially in patients with unrepaired AAA, suggesting the need for continuous cardiovascular risk management.
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Kim et al. (2024) conducted a cohort in Lung cancer with or without abdominal aortic aneurysm (n=4,780). Abdominal aortic aneurysm (AAA) vs. Matched lung cancer patients without AAA was evaluated on All-cause mortality (adjusted HR 1.14, 95% CI 1.06-1.23, p=<0.001). The presence of an abdominal aortic aneurysm in lung cancer patients was associated with a higher risk of all-cause mortality compared to matched controls without AAA.
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