Key result
The presence of an abdominal aortic aneurysm in lung cancer patients was associated with a significantly higher risk of all-cause mortality compared to matched controls without AAA (adjusted HR 1.14).
Why the study?
Major causes of death in abdominal aortic aneurysm patients are cardiovascular disease and cancer, but the effect of abdominal aortic aneurysm on long-term survival in lung cancer patients was unknown.
Does the presence of an abdominal aortic aneurysm increase all-cause mortality in lung cancer patients?
Population
956 lung cancer patients over 50 years of age with degenerative AAA and 3824 matched controls without AAA
Comparison
Lung cancer patients with AAA vs matched lung cancer patients without AAA
Design
Retrospective matched cohort study using an administrative database
Authors
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AAA may raise mortality risk in lung cancer, especially if unrepaired; leaves open whether repair improves outcomes in prospective studies.
Cohort (n=4,780)
Does the presence of an abdominal aortic aneurysm increase all-cause mortality in lung cancer patients?
Hazard Ratio: 1.14 (95% CI 1.06–1.23)
Absolute Event Rate: 57.3% vs 44.8%
p-value: p=<0.001
The presence of an abdominal aortic aneurysm, particularly when untreated, significantly increases the long-term mortality risk in patients with lung cancer, highlighting the need for continuous cardiovascular risk management.
Kim et al. (2024) conducted a cohort in Lung cancer with or without abdominal aortic aneurysm (n=4,780). Abdominal aortic aneurysm (AAA) vs. Matched lung cancer patients without AAA was evaluated on All-cause mortality (adjusted HR 1.14, 95% CI 1.06-1.23, p=<0.001). The presence of an abdominal aortic aneurysm in lung cancer patients was associated with a significantly higher risk of all-cause mortality compared to matched controls without AAA (adjusted HR 1.14).
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