Key result
Among high-risk male patients screened for abdominal aortic aneurysm, the prevalence of lung cancer was 18.0% in those with AAA, and mortality was highest in patients with lung cancer.
Why the study?
Lung diseases are common in patients with abdominal aortic aneurysms, prompting evaluation of the prevalence of lung cancer in high-risk patients screened for AAA.
Cohort (n=601)
Patients with a high cardiovascular risk profile screened for AAA have a high coprevalence of lung cancer, which significantly drives mortality in this population.
Answers are grounded in this paper and cite their sources.
Lung cancer prevalence and mortality are high among AAA patients; hypothesis-generating for combined screening evaluation.
BACKGROUND/AIM: Lung diseases are common in patients with abdominal aortic aneurysms (AAA). This study evaluates the prevalence of lung cancer (LC) in high-risk patients screened for AAA. PATIENTS AND METHODS: Six hundred and one male patients (≥65 years of age, cardiovascular high-risk profile) were enrolled and followed prospectively over a median of 16.5 months. RESULTS: In 29 patients (4.8%) LC and in another 50 patients (8.3%) AAA were found. The prevalence of LC among patients with AAA was even higher (9 of 50, 18.0%). Twenty-one patients had an initial diagnosis of LC, with an incidence of 12.0% (6 of 50) in patients with AAA. During follow-up, 14 of 70 patients with AAA and/ or LC (20.0%) deceased. The highest mortality was found in patients with LC only (8 of 20, 40.0%), followed by patients with both AAA and LC (3 of 9, 33.3%), while patients with AAA only had the lowest mortality rate (3 of 41, 7.3%). CONCLUSION: In patients with a high cardiovascular risk profile, a high prevalence of both AAA and LC were found, whereby the prognosis is largely determined by the LC. Therefore, LC is of particular importance in the setting of screening and surveillance of AAA.
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Hohneck et al. (2020) conducted a cohort in Abdominal Aortic Aneurysm and Lung Cancer (n=601). Abdominal aortic aneurysm vs. Patients without abdominal aortic aneurysm was evaluated on Prevalence of lung cancer and mortality. Among high-risk male patients screened for abdominal aortic aneurysm, the prevalence of lung cancer was 18.0% in those with AAA, and mortality was highest in patients with lung cancer.
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