Hemographic indices are associated with mortality in acute heart failure
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Why the study?
Do hemographic indices predict mortality in patients hospitalized for acute heart failure?
Population
1,923 patients hospitalized primarily for acute heart failure from the HARVEST registry, mean age 76 ± 12…
Design
Cohort
Follow-up
mean 28.6 ± 20.7 months
Authors
Discussion
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Implication
RL may refine mortality prediction in acute HF; leaves open incremental value over standard models.
Structured PICO
Do hemographic indices predict mortality in patients hospitalized for acute heart failure?
P
Population
1,923 patients hospitalized primarily for acute heart failure (AHF) from the HARVEST registry (Taiwan), mean age 76 ± 12 years, 68% men, 21% de novo heart failure. Excluded: severe infection, acute coronary syndrome (ACS), severe hepatic disease, hematopoietic diseases, and active malignancy.
I
Intervention
Hemographic indices measured at first presentation in hospital, including white blood cell (WBC) count, neutrophil count, reciprocal of lymphocyte (RL), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR).
O
Outcome
Mortality (all-cause) during a mean follow-up of 28.6 ± 20.7 months, obtained by linking the database with the National Death Registry.hard clinical
Hemographic indices, particularly the reciprocal of lymphocyte count, serve as independent predictors of short- to medium-term mortality in patients hospitalized for acute heart failure.
Limitations
- Mean age of 76.3 years may limit generalizability to younger populations
- Selection bias inherent to registry study design
- NT-proBNP data only available in 33% of the study population
- Novel inflammatory markers (e.g., IL-6, TNF-alpha) were not measured
- Hemographic indices were not obtained at discharge
- Lack of data on incident morbidities such as re-hospitalization for HF
Cite This Study
Huang et al. (2017) studied this question.
Topics
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