Why the study?
Do astemizole and terfenadine suppress potassium channels in ventricular myocytes?
Do astemizole and terfenadine suppress potassium channels in ventricular myocytes?
Terfenadine and astemizole block potassium channels (IK1, Ito, IK) in ventricular myocytes, providing a mechanistic explanation for their rare proarrhythmic effects such as QT prolongation.
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Offers potential mechanism for proarrhythmia; leaves open applicability to human ventricular myocytes.
Berul et al. (1995) studied this question.
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