Why the study?
Does layer-specific strain analysis detect early cardiac dysfunction in childhood cancer survivors treated with anthracyclines compared to healthy controls?
Does layer-specific strain analysis detect early cardiac dysfunction in childhood cancer survivors treated with anthracyclines compared to healthy controls?
Layer-specific strain analysis reveals that anthracycline-induced myocardial deformation impairment starts in adolescence at the endocardium and progresses towards the epicardium and apex with age, even when LVEF remains normal.
May detect subclinical impairment in anthracycline survivors when LVEF is preserved; hypothesis-generating for surveillance protocols.
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Yazaki et al. (2017) studied this question.
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