Key result
Compared with optimal SBP (117-145 mmHg), higher SBP was associated with increased all-cause mortality (HR 1.34; 95% CI 1.08-1.65) in community-dwelling Chinese adults aged 80 and older.
Why the study?
No studies had simultaneously investigated the non-linear association of systolic blood pressure and resting pulse rate with all-cause and cardiovascular mortality in populations aged 80 and older.
Do systolic blood pressure and resting pulse rate predict all-cause and cardiovascular mortality in community-dwelling octogenarians?
Cohort (n=2,828)
Do systolic blood pressure and resting pulse rate predict all-cause and cardiovascular mortality in community-dwelling octogenarians?
Both high and low systolic blood pressure, as well as faster resting pulse rate, are independent predictors of mortality in community-dwelling adults aged 80 and older, demonstrating a non-linear relationship for SBP.
Systolic blood pressure (SBP) and resting pulse rate (RPR) have been linked to mortality and cardiovascular events in younger population. Till now, no studies simultaneously investigate the non-linear association of SBP and RPR with all-cause and cardiovascular mortality among population aged 80 and older. Data of 2828 eligible participants were selected from electronic health records linked attended automated office blood pressure measurement system. The dose-response relationship between the SBP, RPR, and the risk of all-cause and cardiovascular mortality was analyzed by Cox model with restricted cubic splines. During the 3.6-year follow-up, 442 deaths occurred. Comparing with the optimal SBP (117-145 mmHg), the lower (HR: 1.39, 95% CI: 1.07-1.81) and higher SBP (HR: 1.34, 95% CI: 1.08-1.65) were significantly associated with an increasing risk of all-cause mortality. The higher SBP (>144 mmHg) was associated with cardiovascular mortality, with the HR (95% CI) as 1.51 (1.07-2.12). The faster RPR showed the higher risk of all-cause (HR: 1.36, 95% CI: 1.05-1.76) and cardiovascular (HR: 1.51, 95% CI: 1.07-2.13) mortality. We found both higher SBP and faster RPR were independently associated with all-cause and cardiovascular mortality, and lower SBP was only associated with the increased risk of all-cause mortality in oldest old community-dwelling Chinese population. Our results demonstrate the prognostic importance of both SBP and RPR in the elderly.
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Wang et al. (2021) conducted a cohort in community-dwelling octogenarians (n=2,828). Higher systolic blood pressure (>144 mmHg) vs. Optimal SBP (117-145 mmHg) was evaluated on all-cause mortality (HR 1.34, 95% CI 1.08-1.65). Compared with optimal SBP (117-145 mmHg), higher SBP was associated with increased all-cause mortality (HR 1.34; 95% CI 1.08-1.65) in community-dwelling Chinese adults aged 80 and older.
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