Key result
Higher caffeine consumption was not associated with an increased incidence of atrial fibrillation compared to consuming less than 2 cups per day (1.068; 95% CI 0.937-1.216).
Why the study?
Does caffeine consumption increase the risk of new-onset atrial fibrillation?
Meta-Analysis (n=176,675)
Does caffeine consumption increase the risk of new-onset atrial fibrillation?
Effect estimate: 1.068 (95% CI 0.937-1.216)
Caffeine consumption does not increase the risk of new-onset atrial fibrillation, and high consumption (>436 mg/day) may be associated with a lower incidence.
Supports no caffeine restriction to prevent new-onset AF; confirms neutral association in Level 1 meta-analysis.
OBJECTIVE: Caffeine has been considered a trigger for atrial fibrillation (AF). We conducted a meta-analysis including a dose-response analysis to assess the relationship between caffeine consumed and incidence of AF. METHODS: Data from selected studies represented 176,675 subjects (AF in 9,987 [5.7%]). Caffeine content varied widely, ranging from 40 to 180 mg per cup of coffee. For purposes of the calculations in this study, we assumed 140 mg of caffeine in a standard 12-oz cup of coffee. RESULTS: No significant difference was found in AF incidence when the subjects consuming less than 2 cups of coffee per day were compared to subjects with higher consumption, 1.068 (0.937-1.216). The risk of AF was higher among subjects consuming less than 2 cups of coffee daily when compared to higher daily consumption subjects. A lower incidence of AF was found among people consuming more than 436 mg daily. CONCLUSION: The incidence of AF is not increased by coffee consumption. In fact, we found a lower incidence of AF when caffeine consumption exceeded 436 mg/day. Therefore, based on available evidence there is no association between caffeine intake and AF risk.
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Abdelfattah et al. (2018) conducted a meta-analysis in Atrial fibrillation (n=176,675). Caffeine consumption vs. Less than 2 cups of coffee per day was evaluated on Incidence of atrial fibrillation (1.068, 95% CI 0.937-1.216). Higher caffeine consumption was not associated with an increased incidence of atrial fibrillation compared to consuming less than 2 cups per day (1.068; 95% CI 0.937-1.216).
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