Standardized diagnostic scoring systems and tailored multidrug regimens featuring SGLT2 inhibitors are recommended as the mainstay of HFpEF management in Egypt to address current clinical challenges.
This expert consensus provides tailored recommendations for the diagnosis and management of HFpEF in Egypt, emphasizing the use of the H2FPEF score and SGLT2 inhibitors.
Heart failure with preserved ejection fraction (HFpEF) is an ongoing challenge for healthcare systems. Major limitations that hinder adequate control of the disease, including an incomplete understanding of its pathophysiology, limited therapy options, and the absence of sufficient information on the management of comorbidities. Diagnosis and management of HFpEF in Egypt lack standardization as they are complicated with multiple comorbidities and limited by the lack of resources and data on epidemiology and patient characteristics. Diagnostic procedures for HFpEF should be implemented through guideline-specified scoring systems, due to the heterogeneity of clinical presentations and the absence of a golden standard for confirming HFpEF. In Egypt, the H2FPEF scoring system is more commonly used for establishing HFpEF diagnosis. All HFpEF patients should be treated through multidrug regimens tailored for their state, symptoms, and comorbidities, with sodium-glucose cotransporter-2 (SGLT2) inhibitors as the mainstay of treatment together with either one or a combination of loop diuretic and aldosterone antagonists. This paper provides an integrated review of epidemiology, means of diagnosis, current and novel pharmacological therapy options for HFpEF patients in the light of the recent advances in treatment of HFpEF, discussing means of healthcare delivery and unmet needs, and proposing recommendations for clinical practice and pathways for future research.
Abdelhamid et al. (Wed,) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Standardized diagnostic scoring systems and tailored multidrug regimens featuring SGLT2 inhibitors are recommended as the mainstay of HFpEF management in Egypt to address current clinical challenges.