Why the study?
Does streptozotocin-induced diabetes reduce myocardial blood flow reserve in rats?
Does streptozotocin-induced diabetes reduce myocardial blood flow reserve in rats?
In a rat model, streptozotocin-induced diabetes leads to functional alteration of the coronary microcirculation and decreased capillary density, resulting in reduced myocardial blood flow reserve.
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Impaired myocardial blood flow reserve in diabetic rats supports microvascular dysfunction; leaves open translation to human diabetic cardiomyopathy.
Cosyns et al. (2008) studied this question.
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