Key result
Over ~90% of heart failure patients carry at least two comorbidities, led overwhelmingly by hypertension.
Why the study?
Heart failure is associated with comorbidities that impair outcomes and increase economic burden, prompting evaluation of comorbidity burden and demographic relationships in Türkiye.
Cohort (n=2,722,151)
Yes
This nationwide study of over 2.7 million heart failure patients in Türkiye demonstrates an exceptionally high burden of multimorbidity—with over 90% having at least two comorbidities and nearly universal hypertension—highlighting the critical need for holistic, age- and sex-specific comorbidity management in heart failure care.
Answers are grounded in this paper and cite their sources.
High multimorbidity burden in HF supports integrated care models; leaves open whether comorbidity-targeted interventions improve outcomes.
Background/aim: Heart failure (HF) is associated with a wide range of comorbidities that negatively impact clinical outcomes and cause high economic burden. We aimed to evaluate the frequency and burden of comorbidities in HF patients in Türkiye and their relationships with patients' demographic characteristics. Materials and methods: Based on ICD-10 codes in the national electronic database of the Turkish Ministry of Health covering the entire population of Türkiye (n = 85,279,553) from 1 January 2016 to 31 December 2022, data on the prevalence of comorbidities in HF patients were obtained. The frequency and burden of comorbidities were analyzed separately by age groups, sex, and socioeconomic status (SES). Results: Between 2016 and 2022, there were 2,722,151 patients (51.7% female) of all ages who were diagnosed with HF. In Türkiye, the most common comorbidities of HF patients were hypertension (HT) (97.6%), atherosclerotic cardiovascular disease (ASCVD) (84.9%), dyslipidemia (59.5%), anxiety disorder (48.1%), diabetes mellitus (DM) (45.2%), chronic obstructive pulmonary disease (COPD) (43.6%), anemia (40.6%), and atrial fibrillation (AF) (37.1%). Female patients had higher rates of anemia, DM, HT, and anxiety disorders, while male patients had higher rates of ASCVD, COPD, and dyslipidemia. The most common comorbidity in patients under 20 years of age was congenital heart disease (52.3%). More than 90% of HF patients had ≥2 comorbidities. HF patients with ≥5 comorbidities increased from 18.1% in the group aged 20-49 years to 38.3% in the group aged 50-79 years. Comorbidities were similar across SES groups. Conclusion: The most common comorbidities in cases of HF in Türkiye are HT, ASCVD, dyslipidemia, DM, COPD, anemia, and AF, respectively, and more than 90% of patients have ≥2 comorbidities. While ASCVD and dyslipidemia were more common in male patients, anemia, DM, and anxiety disorders were more common in female patients. The number of comorbid conditions increased with advanced age.
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Çavuşoğlu et al. (2024) conducted a cohort in Heart Failure (HF) (n=2,722,151). Heart failure diagnosis and demographic stratification (age, sex, socioeconomic status) was evaluated on Prevalence and burden of comorbidities in heart failure patients. Among 2,722,151 heart failure patients in Türkiye, >90% had ≥2 comorbidities, led by hypertension, ASCVD, dyslipidemia, anxiety, and diabetes.
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