Key result
Losartan/hydrochlorothiazide (50/12.5 mg) was superior to 100-mg losartan for achieving controlled blood pressure in patients with isolated morning hypertension (81.8% vs 21.4%, p=0.003).
Why the study?
Does a 50-mg losartan/12.5-mg hydrochlorothiazide combination improve blood pressure control compared to 100-mg losartan in treated hypertensive patients with morning hypertension?
RCT (n=110)
Does a 50-mg losartan/12.5-mg hydrochlorothiazide combination improve blood pressure control compared to 100-mg losartan in treated hypertensive patients with morning hypertension?
Absolute Event Rate: 81.8% vs 21.4%
p-value: p=0.003
A fixed-dose combination of losartan/hydrochlorothiazide is significantly more effective than high-dose losartan for controlling isolated morning hypertension.
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Supports losartan/HCTZ over high-dose losartan for morning hypertension; extends randomized evidence for fixed-dose combinations in isolated morning BP.
Kai et al. (2015) conducted an RCT in Morning hypertension (n=110). Losartan/hydrochlorothiazide vs. 100-mg losartan was evaluated on Controlled hypertension (morning and evening BP < 135/85 mmHg) in patients with isolated morning hypertension (p=0.003). Losartan/hydrochlorothiazide (50/12.5 mg) was superior to 100-mg losartan for achieving controlled blood pressure in patients with isolated morning hypertension (81.8% vs 21.4%, p=0.003).
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