Why the study?
Do single doses of captopril, hydrochlorothiazide, or their combination alter 24-h urinary excretions of water and solutes in healthy volunteers?
Do single doses of captopril, hydrochlorothiazide, or their combination alter 24-h urinary excretions of water and solutes in healthy volunteers?
Captopril has prolonged renal excretory actions and uricosuric properties, while its combination with hydrochlorothiazide significantly increases fluid and electrolyte excretion.
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Limits generalizability from healthy volunteers; extends evidence of captopril-HCTZ synergy on natriuresis and diuresis.
Leary et al. (1985) studied this question.
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