Why the study?
Does controlling renal perfusion pressure affect the onset of cerebrovascular lesions in stroke-prone spontaneously hypertensive rats?
Population
Stroke-prone spontaneously hypertensive rats kept under normal or salt-loaded conditions
Comparison
Control of renal perfusion pressure by aortic… vs Unclamped controls
Design
Preclinical
Authors
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Suggests renal perfusion pressure modulates lesion onset in hypertensive rats; leaves open relevance to human cerebrovascular disease.
Does controlling renal perfusion pressure affect the onset of cerebrovascular lesions in stroke-prone spontaneously hypertensive rats?
Reduction in renal perfusion pressure and/or renal ischemia may be related to the pathogenesis of cerebrovascular lesions in stroke-prone spontaneously hypertensive rats.
Nagaoka et al. (1980) studied this question.
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