Key result
Definite stent thrombosis after second-generation DES implantation was associated with higher 4-year mortality compared to controls (e.g., 33.0% vs 12.3% for early ST; P<0.001).
Why the study?
Risk factors and long-term clinical outcomes of patients with definite stent thrombosis after second-generation drug-eluting stent implantation have not been adequately assessed.
What are the risk factors and long-term mortality outcomes associated with definite stent thrombosis after second-generation drug-eluting stent implantation?
Population
313 patients with definite second-generation DES ST and matched controls without definite ST
Comparison
Definite ST (early, late, or very late) vs matched controls without definite ST
Design
Retrospective multicenter registry (case-control)
Follow-up
4 years
Authors
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Supports continued vigilance for ST after second-generation DES; leaves open targeting of timing-specific risk factors.
Case-Control (n=1,565)
Yes
What are the risk factors and long-term mortality outcomes associated with definite stent thrombosis after second-generation drug-eluting stent implantation?
Absolute Event Rate: 33% vs 12.3%
p-value: p=<0.001
Definite stent thrombosis after second-generation DES implantation has distinct risk factors depending on its timing and is associated with significantly higher long-term mortality compared to patients without stent thrombosis.
Kuramitsu et al. (2019) conducted a case-control in Definite stent thrombosis after second-generation DES implantation (n=1,565). Definite stent thrombosis vs. No definite stent thrombosis was evaluated on Cumulative 4-year incidence of death (p=<0.001). Definite stent thrombosis after second-generation DES implantation was associated with higher 4-year mortality compared to controls (e.g., 33.0% vs 12.3% for early ST; P<0.001).
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