Why the study?
Does short-term administration of heparin improve renal function and fibrinogen catabolism in patients with oliguria?
Does short-term administration of heparin improve renal function and fibrinogen catabolism in patients with oliguria?
Short-term heparin administration may increase glomerular filtration rate and improve fibrinogen catabolism in patients with accelerated hypertension and transplant rejection, but appears ineffective for oliguric glomerulonephritis.
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Hypothesis-generating for heparin in accelerated hypertension; does not support use in oliguric glomerulonephritis.
The effect of short-term administration of heparin has been studied in seven patients with oliguric glomerulonephritis, five with accelerated hypertension, and three with transplant rejection. Measurements were made of the glomerular filtration rate, radiofibrinogen catabolism, and complement inhibition. Beneficial effects on fibrinogen catabolism were found in some cases of accelerated hypertension and transplant rejection, but heparin alone had no dramatic effect in glomerulonephritis. Heparin produced an increase of glomerular filtration rate, but in-vivo inhibition of complement by heparin was small.
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Wardle et al. (1972) studied this question.
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