Changes in biochemical parameters related to atherosclerosis after Helicobacter pylori eradication

Summary Background Recent evidence suggests that Helicobacter pylori infection is involved in the pathogenesis of extra‐gastrointestinal diseases such as coronary heart disease. Aim To determine the association of H. pylori infection with biochemical parameters of atherosclerosis in the serum. Methods One hundred and fifty‐nine patients with H. pylori ‐positive peptic ulcer (duodenal ulcer, n=89; gastric ulcer, n=70) receiving triple therapy were studied prospectively for up to 3 years for clinical parameters associated with inflammation and cardiovascular events. Blood was tested at the time of annual check‐up. Results Eradication was successful in 137 patients (86%), and body weight, body mass index (BMI) and TG levels increased gradually each year. No significant hanges were seen in plasma levels of total cholesterol, interleukin‐6 or interleukin‐8, whereas those of HDL‐C increased significantly, and those of C‐reactive protein, fibrinogen and LDL‐C decreased. Conclusion There is evidence for the possible implication of H. pylori infection in the etiology of cardiovascular events via its exacerbation of or influence on risk factors of atherogenesis.