Key result
Stem cell sheet transplantation attenuates cardiac dysfunction and improves heart failure manifestations after myocardial infarction.
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Stem cell-derived sheet engineering has been developed as the next-generation treatment for myocardial infarction (MI) and offers attractive advantages in comparison with direct stem cell transplantation and scaffold tissue engineering. Furthermore, induced pluripotent stem cell-derived cell sheets have been indicated to possess higher potential for MI therapy than other stem cell-derived sheets because of their capacity to form vascularized networks for fabricating thickened human cardiac tissue and their long-term therapeutic effects after transplantation in MI. To date, stem cell sheet transplantation has exhibited a dramatic role in attenuating cardiac dysfunction and improving clinical manifestations of heart failure in MI. In this review, we retrospectively summarized the current applications and strategy of stem cell-derived cell sheet technology for heart tissue repair in MI.
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Guo et al. (2020) conducted a review in Myocardial infarction. Stem cell-derived cell sheet transplantation vs. Direct stem cell transplantation and scaffold tissue engineering was evaluated on Attenuation of cardiac dysfunction and improvement in clinical manifestations of heart failure. Stem cell-derived cell sheet transplantation attenuates cardiac dysfunction and improves heart failure manifestations in myocardial infarction, with iPSC-derived sheets showing high potential.
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