Why the study?
Does heart cell transplantation improve heart function in a hamster model of dilated cardiomyopathy?
Population
36 adult hamsters (17 weeks old) with dilated cardiomyopathy (BIO 53.58 strain)
Comparison
Transplantation of 4 x 10^6 cultured ventricular… vs Transplantation of culture medium or sham…
Design
Preclinical
Follow-up
4 weeks
Authors
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Supports cell therapy development in cardiomyopathy models; hypothesis-generating and should not yet influence clinical practice.
Does heart cell transplantation improve heart function in a hamster model of dilated cardiomyopathy?
Transplantation of ventricular heart cells into the myocardium of dilated cardiomyopathic hamsters forms cardiac-like tissue and improves contractile function.
Yoo et al. (2000) studied this question.
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