Mortality Among Referral Patients With Hypertrophic Cardiomyopathy vs the General European Population
Why the study?
It was unclear whether hypertrophic cardiomyopathy conveys excess mortality compared with the general population.
Does hypertrophic cardiomyopathy convey excess mortality compared with the general European population?
Population
4893 consecutive adult patients with HCM presenting at 7 European referral centers
Comparison
Patients with HCM vs the general European population
Design
Multicenter retrospective cohort study
Follow-up
Median 6.2 years
Authors
Discussion
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Member takes
Implication
Should not assume near-normal contemporary survival; leaves open generalizability beyond European referral centers.
Structured PICO
Does hypertrophic cardiomyopathy convey excess mortality compared with the general European population?
P
Population
4893 consecutive adult patients with hypertrophic cardiomyopathy (HCM) presenting at 7 European referral centers between 1980 and 2013, mean age 49.2, 63.9% male.
C
Comparator
General European population (data from Eurostat)
O
Outcome
Survival compared using standardized mortality ratios (SMRs) and a composite end point in the HCM cohort of all-cause mortality, aborted sudden cardiac death, and heart transplantcomposite
Hypertrophic cardiomyopathy is associated with significant excess mortality compared to the general European population, with women experiencing higher excess mortality than men.
Cite This Study
Lorenzini et al. (2019) studied this question.