April 27, 2026Journal of the American College of Cardiology
Hypertrophic Cardiomyopathy in Adulthood Associated With Low Cardiovascular Mortality With Contemporary Management Strategies
Key result
Contemporary adult HCM management shows a low 0.53% annual disease-related mortality rate.
- n=1,000
Why the study?
HCM was historically associated with adverse outcomes and annual mortality up to 6%, prompting evaluation of whether recent management advances have improved survival and clinical course in adults.
Population
1,000 consecutive adult HCM patients presenting at 30 to 59 years of age
Design
Cohort study
Follow-up
7.2±5.2 years
Authors
Discussion
Loading...
Member takes
Implication
Reassures clinicians managing adult HCM; leaves open which contemporary strategies drive survival benefit pending randomized trials.
Key Points
- This study aimed to evaluate the impact of recent management strategies on survival in adult patients with hypertrophic cardiomyopathy.
- Analyzed long-term outcomes in 1,000 adult patients aged 30 to 59 years with hypertrophic cardiomyopathy over 7.2 years of follow-up.
- Evaluated the effects of interventions such as ICDs and heart transplantation on mortality and clinical symptoms.
- Assessed predictors of adverse outcomes in the cohort.
- 918 patients (92%) survived to an average age of 53 years, with 91% reporting mild or no symptoms.
- HCM-related deaths occurred in 4% of patients, primarily due to heart failure and arrhythmic events (0.53% per year).
- 5- and 10-year survival rates for HCM-related deaths were 98% and 94%, not significantly different from the general U.S. population (p=0.25).
Study Design
Type
Cohort (n=1,000)
PICO
P
Population
Hypertrophic cardiomyopathy (n=1,000)
I
Intervention / Comparator
Contemporary management strategies vs General U.S. population
O
Primary Outcome
HCM-related death
Cite This Study
Maron et al. (2015) conducted a cohort in Hypertrophic cardiomyopathy (n=1,000). Contemporary management strategies vs. General U.S. population was evaluated on HCM-related death. Contemporary management strategies in adult hypertrophic cardiomyopathy resulted in a low disease-related mortality rate of 0.53%/year, with 5- and 10-year survival rates of 98% and 94%.