Why the study?
Does tight maternal glucose control with continuous subcutaneous insulin infusion normalize fetal circulation in type-1 diabetic pregnancies compared to normal pregnancies?
Population
17 fetuses of women with well-controlled type-I diabetes
Comparison
Maternal continuous subcutaneous insulin… vs Normal fetal data obtained in previous studies
Design
Cohort
Follow-up
Longitudinal from 15 weeks' gestation at 4-week intervals
Authors
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Altered fetal hemodynamics persist despite tight maternal control; hypothesis-generating for mechanisms and interventions to prevent hypertrophy.
Does tight maternal glucose control with continuous subcutaneous insulin infusion normalize fetal circulation in type-1 diabetic pregnancies compared to normal pregnancies?
Fetuses of mothers with well-controlled type-1 diabetes still exhibit altered cardiac circulation, suggesting compensatory mechanisms that increase cardiac output and may lead to hypertrophy.
Lisowski et al. (2003) studied this question.
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