Clinical Validation of a Novel High-Sensitivity Cardiac Troponin I Assay for Early Diagnosis of Acute Myocardial Infarction
Why the study?
Does the Siemens-hs-cTnI-Centaur assay provide comparable diagnostic accuracy to established high-sensitivity troponin assays for the early diagnosis of acute myocardial infarction in patients presenting to the emergency department?
Population
1,755 patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction
Comparison
Novel high-sensitivity cardiac troponin I assay… vs Established high-sensitivity cardiac troponin…
Design
Cohort, Final diagnoses centrally adjudicated by 2 independent cardiologists
Follow-up
2 hours
Authors
Discussion
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Member takes
Implication
May support Siemens assay adoption in ED settings; leaves open impact on clinical outcomes.
Structured PICO
Does the Siemens-hs-cTnI-Centaur assay provide comparable diagnostic accuracy to established high-sensitivity troponin assays for the early diagnosis of acute myocardial infarction in patients presenting to the emergency department?
P
Population
1,755 patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction (AMI)
I
Intervention
Novel high-sensitivity cardiac troponin I assay (Siemens-hs-cTnI-Centaur) measured at presentation, 1 h, and 2 h
C
Comparator
Established high-sensitivity cardiac troponin assays (Roche-hs-cTnT-Elecsys and Abbott-hs-cTnI-Architect)
O
Outcome
Diagnostic accuracy quantified by the area under the ROC curve (AUC) at presentationsurrogate
The novel Siemens-hs-cTnI-Centaur assay demonstrates high diagnostic accuracy comparable to established high-sensitivity troponin assays for the early diagnosis of acute myocardial infarction.
Cite This Study
Boeddinghaus et al. (2018) studied this question.