What question did this study set out to answer?

To investigate the interrelationships between high-sensitivity C-reactive protein (CRP), left atrial (LA) volume, and the risk of developing a first episode of atrial fibrillation (AF) in high-risk elderly individuals.

January 13, 2010EchocardiographyOpen Access

C‐Reactive Protein, Left Atrial Volume, and Atrial Fibrillation: A Prospective Study in High‐Risk Elderly

View Full Paper

Ask AI

Bookmark

Why the study?

Do CRP and indexed LA volume predict the development of first atrial fibrillation in high-risk elderly patients?

Key Points

To investigate the interrelationships between high-sensitivity C-reactive protein (CRP), left atrial (LA) volume, and the risk of developing a first episode of atrial fibrillation (AF) in high-risk elderly individuals.
Prospective cohort study (SAFHIRE) of 800 participants aged ≥65 years (mean age 74 ± 6 years) with ≥2 AF risk factors followed for 1.7 ± 0.9 years.
Participants underwent annual clinical evaluations, blood work, electrocardiograms, and echocardiograms to monitor for incident AF and measure CRP and LA volume.
First AF developed in 34 of 800 participants during follow-up.
CRP was not associated with LA volume and did not predict first AF in univariable or multivariable analyses (all P > 0.10).
Indexed LA volume independently predicted first AF (multivariable-adjusted HR 1.3 per 5 ml/m², 95% CI 1.09 to 1.48, P = 0.001).

Structured PICO

Do CRP and indexed LA volume predict the development of first atrial fibrillation in high-risk elderly patients?

Population

800 elderly patients (aged ≥65 years) with ≥2 other atrial fibrillation risk factors (systemic hypertension, proven coronary artery disease, heart failure, diabetes), mean age 74, 97% with systemic hypertension, 78% with proven coronary artery disease.

Intervention

Assessment of high-sensitive C-reactive protein (CRP) and indexed left atrial (LA) volume

Outcome

Development of first atrial fibrillation (AF) over 1.7 +/- 0.9 yearshard clinical

In high-risk elderly patients, indexed left atrial volume, but not CRP, is an independent predictor of incident atrial fibrillation.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

May support LA volume for AF risk stratification in elderly patients; hypothesis-generating for CRP and needs prospective validation.

Cite This Study

Casaclang‐Verzosa et al. (2010) studied this question.

synapsesocial.com/papers/6a7f66c1c47bc9bb3efbf6fa https://doi.org/10.1111/j.1540-8175.2009.01039.x

Topics

Atrial fibrillation Persistent AF management Coronary artery disease Hypertension management Anticoagulation in AF

View Full Paper

Ask AI

Bookmark

C‐Reactive Protein, Left Atrial Volume, and Atrial Fibrillation: A Prospective Study in High‐Risk Elderly

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

C‐Reactive Protein, Left Atrial Volume, and Atrial Fibrillation: A Prospective Study in High‐Risk Elderly

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider