December 1, 1988AJP Cell Physiology

pH regulation in single glomerular mesangial cells. II. Na+-dependent and -independent Cl(-)-HCO3- exchangers

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Population

single renal glomerular mesangial cells

Design

Preclinical

Authors

GBG. BoyarskyThe University of Texas Medical Branch at Galveston MGMichael B. GanzCleveland Clinic RSR. Bernd SterzelLeiden University

Discussion

Member takes

Implication

The study identifies that acid extrusion in renal mesangial cells involves a Na+-dependent Cl(-)-HCO3- exchanger, while acid loading involves a Na+-independent Cl(-)-HCO3- exchanger.

Structured PICO

Population

single renal glomerular mesangial cells

Intervention

manipulation of external Na+ and Cl- concentrations in the presence of CO2-HCO3-

Outcome

intracellular pH (pHi) regulation and rate of recovery from an acid loadsurrogate

The study identifies that acid extrusion in renal mesangial cells involves a Na+-dependent Cl(-)-HCO3- exchanger, while acid loading involves a Na+-independent Cl(-)-HCO3- exchanger.

Cite This Study

Boyarsky et al. (1988) studied this question.

synapsesocial.com/papers/6a7f6a2ac47bc9bb3efbfa88 https://doi.org/10.1152/ajpcell.1988.255.6.c857

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Implication

The study identifies that acid extrusion in renal mesangial cells involves a Na+-dependent Cl(-)-HCO3- exchanger, while acid loading involves a Na+-independent Cl(-)-HCO3- exchanger.

pH regulation in single glomerular mesangial cells. II. Na+-dependent and -independent Cl(-)-HCO3- exchangers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

pH regulation in single glomerular mesangial cells. II. Na+-dependent and -independent Cl(-)-HCO3- exchangers

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider