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October 1, 1994Circulation

Treatment of myocardial infarction in the United States (1990 to 1993). Observations from the National Registry of Myocardial Infarction.

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Why the study?

How is acute myocardial infarction managed in clinical practice in the United States compared to clinical trial recommendations?

Population

240,989 patients with acute myocardial infarction enrolled at 1,073 US hospitals collaborating in the…

Design

Cohort

Authors

WRWilliam J. RogersLBLaura J. BowlbyNCNisha C. Chandra

Discussion

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Overview

Documents 1990s US gaps in thrombolytic, aspirin, and beta-blocker use for AMI; leaves open whether contemporary practice has closed them.

Structured PICO

How is acute myocardial infarction managed in clinical practice in the United States compared to clinical trial recommendations?

P
Population
240,989 patients with acute myocardial infarction enrolled at 1,073 US hospitals collaborating in the National Registry of Myocardial Infarction during 1990 through 1993.
I
Intervention
Real-world management of acute myocardial infarction, including thrombolytic therapy, pharmacotherapy, and invasive procedures.
O
Outcome
Treatment patterns, including use of thrombolytic therapy, time to treatment, concomitant pharmacotherapy, and invasive procedures.

This large US registry from 1990-1993 highlights significant gaps between clinical trial recommendations and real-world practice in acute myocardial infarction management, including underuse of thrombolytics, aspirin, and beta-blockers.

Cite This Study

Rogers et al. (1994) studied this question.

synapsesocial.com/papers/6a7f6c87b29ac8bf76e8f89ehttps://doi.org/10.1161/01.cir.90.4.2103
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Also Consider

Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Analysis of Time Delays Preceding Thrombolysis for Acute Myocardial Infarction1989 · 166 citations
  2. 2Outcome of Patients with Acute Myocardial Infarction Who Are Ineligible for Thrombolytic Therapy1991 · 192 citations
  3. 3The Association between On-Site Cardiac Catheterization Facilities and the Use of Coronary Angiography after Acute Myocardial Infarction1993 · 237 citations