January 1, 1969Japanese Journal of MicrobiologyOpen Access

Comparative Sensitivity of Various Tissue Cultures for Isolation of Coxsackievirus B3

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Population

266 rectal swabs obtained from children, ages 0 to 11 from a small town in northern Honshu during August 1966

Comparison

HEp-2 and VERO cell lines vs Primary human embryonic kidney cells and human…

Design

Preclinical

Authors

RKR KawanaIwate Medical University IMIchiro MatsumotoHamamatsu University

Discussion

Member takes

Implication

May guide cell line selection for CVB3 isolation in labs; leaves open standardization for clinical diagnostics.

Structured PICO

Population

266 rectal swabs obtained from children, ages 0 to 11 from a small town in northern Honshu during August 1966

Intervention

HEp-2 and VERO cell lines

Comparator

Primary human embryonic kidney (PHEK) cells and human embryonic lung diploid (DHEL) cells

Outcome

Sensitivity for isolation of coxsackievirus B3 (measured by isolation rates, time of appearance and rapidity of progress of cytopathic effect, and infectious titer)surrogate

HEp-2 and VERO cell lines are more sensitive than PHEK and DHEL cells for the isolation of coxsackievirus B3 from clinical specimens.

Cite This Study

Kawana et al. (1969) studied this question.

synapsesocial.com/papers/6a7f72ce25d25dc938681ef8 https://doi.org/10.1111/j.1348-0421.1969.tb00437.x

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Comparative Sensitivity of Various Tissue Cultures for Isolation of Coxsackievirus B3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparative Sensitivity of Various Tissue Cultures for Isolation of Coxsackievirus B3

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider