Key result
RD-18S cells demonstrated a substantially higher isolation rate for Group A Coxsackieviruses from clinical specimens (63.6%) compared to original RD cells (14.3%).
Population
RD cells, RD-18S cloned cells, suckling mice, GMK, HEL, HeLa cells, and clinical specimens
Comparison
Use of RD-18S cloned cell line vs RD cells, suckling mice, GMK, HEL, HeLa cells
Design
Preclinical
Authors
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May improve enteroviral isolation in research labs; leaves open routine clinical adoption pending validation.
Absolute Event Rate: 63.6% vs 14.3%
The RD-18S cloned cell line is highly sensitive to Group A Coxsackieviruses and ECHO viruses, significantly improving virus isolation rates from clinical specimens compared to standard cell lines.
Sakae et al. (1985) studied Enterovirus infection (Group A Coxsackieviruses and ECHO viruses). RD-18S cells vs. RD cells, GMK, HEL, HeLa cells, and suckling mice was evaluated on Isolation rate of Group A Coxsackieviruses from clinical specimens. RD-18S cells demonstrated a substantially higher isolation rate for Group A Coxsackieviruses from clinical specimens (63.6%) compared to original RD cells (14.3%).
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