The RD-9H8 cloned cell line is highly sensitive to Coxsackievirus Group B and is useful for measuring neutralizing antibodies.
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RD-9H8 cells may support Coxsackie B serology assays; leaves open prospective validation before clinical use.
We carried out cloning of RD cells and obtained cloned cell line RD-9H8, which is highly sensitive to enteroviruses. Cytopathic effect (CPE) of RD-9H8 cells was more remarkable than that of original RD cells. The RD-9H8 cells were used to measure the neutralizing antibodies to coxsackievirus group B in sera from 93 medical students collected in Oct. 1990 at Iwate Medical University. The proportions of confirmed positive sera were coxsackievirus type B1 44.1%, type B2 50.5%, type B3 46.2%, type B4 64.5%, type B5 53.8% and type B6 4.4%.
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Yanagihara et al. (1992) studied this question.
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