Why the study?
Does atrial natriuretic factor decrease cell volume in rabbit atrial and ventricular myocytes?
Does atrial natriuretic factor decrease cell volume in rabbit atrial and ventricular myocytes?
ANF decreases the volume of atrial and ventricular myocytes, potentially acting as a negative feedback mechanism for stretch-induced ANF release and contributing to cell volume maintenance in heart failure.
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ANF reduces myocyte volume in rabbits; leaves open relevance to human HF volume regulation and stretch feedback.
Clemo et al. (1991) studied this question.
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