What question did this study set out to answer?

To evaluate the clinical features, risk factors, and short-term recovery outcomes in patients experiencing neutropenia from low-dose methotrexate therapy.

November 29, 2024Ulusal Romatoloji DergisiOpen Access

Retrospective analysis of cases with low dose methotrexate-induced neutropenia

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Authors

EDElif DincsesIstanbul Medeniyet University SBSevilay BatıbayIstanbul Eye Hospital

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Implication

Retrospective study reports rapid hematologic recovery with leucovorin in patients with methotrexate-induced neutropenia, indicating improper daily dosing as the primary cause of toxicity.

Key Points

To evaluate the clinical features, risk factors, and short-term recovery outcomes in patients experiencing neutropenia from low-dose methotrexate therapy.
Retrospectively analyzed adult patients (N=9, mean age 71 years) admitted with low-dose methotrexate-related neutropenia (neutrophil count <1500/mm³) between October 2022 and April 2024.
Assessed methotrexate dosing frequency, clinical presentation, baseline laboratory values, recovery duration on intravenous leucovorin monotherapy without granulocyte-colony stimulating factor, and mortality.
Improper daily methotrexate use (7.5–15 mg/day) occurred in 7 of 9 patients, with 7 presenting with pancytopenia, 8 with mucositis, and 3 with febrile neutropenia.
At presentation, mean leukocyte count was 1520/mm³, neutrophil count was 600/mm³, hemoglobin was 8.7 g/dL, and platelet count was 66000/mm³.
Intravenous leucovorin monotherapy led to neutropenia improvement in a mean of 8 days and leukopenia improvement in 8.6 days, with 0% mortality.

Cite This Study

Dincses et al. (2024) studied this question.

synapsesocial.com/papers/6a7f8a4c8cb2fb2788a6f886 https://doi.org/10.4274/raed.galenos.2024.39358

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Implication

Retrospective study reports rapid hematologic recovery with leucovorin in patients with methotrexate-induced neutropenia, indicating improper daily dosing as the primary cause of toxicity.

Retrospective analysis of cases with low dose methotrexate-induced neutropenia

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Implication

Key Points

Cite This Study

Retrospective analysis of cases with low dose methotrexate-induced neutropenia

Discussion

Member takes

Implication

Key Points

Cite This Study

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