July 1, 1999British Journal of PharmacologyOpen Access

Separation of M‐like current and ERG current in NG108‐15 cells

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Population

Differentiated NG108-15 neuroblastoma x glioma hybrid cells

Design

Preclinical

Authors

HMH. MevesMarine Biological Association of the United Kingdom JSJürgen R. SchwarzUniversität Hamburg IWIris WulfsenUniversität Hamburg

Discussion

Member takes

Implication

Provides selective tools to dissect M-like and ERG currents in vitro; leaves open cardiac translation.

Structured PICO

Population

Differentiated NG108-15 neuroblastoma x glioma hybrid cells

Intervention

Linopirdine, WAY-123.398, and E-4031

Outcome

Inhibition of fast and slow components of deactivation currentssurrogate

In NG108-15 cells, the fast component of deactivation current is an M-like current (likely KCNQ2/KCNQ3) and the slow component is an ERG current (likely ERG1/ERG2).

Cite This Study

Meves et al. (1999) studied this question.

synapsesocial.com/papers/6a7f943d138fa0ec199fe83a https://doi.org/10.1038/sj.bjp.0702642

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Separation of M‐like current and ERG current in NG108‐15 cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Separation of M‐like current and ERG current in NG108‐15 cells

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider