Population
NG108-15 neuroblastoma x glioma cells
Comparison
Culture in serum-free medium and administration… vs Undifferentiated cells in growth media or cells…
Design
Preclinical
Authors
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Supports Kir involvement in neuronal cell-line differentiation; hypothesis-generating and leaves open relevance to primary neurons or in vivo systems.
Inwardly rectifying K+ channels play a crucial role in determining resting membrane potential and triggering morphological differentiation in NG108-15 cells.
Pancrazio et al. (1999) studied this question.
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