August 1, 1999Journal of Neurobiology

Modulation of HERG current andherg gene expression during retinoic acid treatment of human neuroblastoma cells: Potentiating effects of BDNF

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Population

SH-SY5Y human neuroblastoma (NB) cells

Design

Preclinical

Follow-up

up to 6 days

Authors

AAAnnarosa ArcangeliElectrophysiology BRBarbara RosatiStony Brook School OCOlivia CrocianiTumour Institute of Tuscany

Discussion

Member takes

Implication

Caution against clinical translation in neuroblastoma; leaves open RA-BDNF effects on HERG in differentiation models.

Structured PICO

Population

SH-SY5Y human neuroblastoma (NB) cells

Intervention

all-trans-retinoic acid (RA) with or without brain-derived neurotrophic factor (BDNF)

Outcome

Modulation of herg gene transcription and HERG currents (I(HERG))surrogate

Retinoic acid induces neuronal differentiation and increases HERG current density in neuroblastoma cells, an effect potentiated by BDNF, highlighting a mechanism for resting potential hyperpolarization in cancer cells.

Cite This Study

Arcangeli et al. (1999) studied this question.

synapsesocial.com/papers/6a859b5cb451cea71dae6e6e https://doi.org/10.1002/(sici)1097-4695(199908)40:2<214::aid-neu7>3.0.co;2-0

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