Why the study?
Although myosin II motor domain structure and function are well understood, the myosin filament backbone is not, leaving ambiguities in non-myosin densities.
Population
Flight muscle thick filaments from Drosophila melanogaster
Design
Structural analysis at 4.7 Å resolution
Authors
Loading...
Hypothesis-generating for thick filament regulation in cardiac muscle; leaves open translation to human sarcomereopathies pending mammalian validation.
High-resolution structural analysis of Drosophila flight muscle thick filaments reveals how flightin and myofilin cooperate to define filament structure.
Yeganeh et al. (2023) studied this question.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: